ADMISSION OPEN - 2017-18 PUEET/PULAT 2017 PGCET - 2017

Research & Publications

 An article by Dr. Arabinda Bhandari,
Prof. School of Management

On “SMAC- ING ADVANTAGE IN STRATEGIC RETAIL LOYALTY PROGRAM – A CASE STUDY IN INDIAN PHARMACEUTICAL INDUSTRY” was published by “International Journal of Strategic  Management” (IJSM), USA. 

 

 

 

Research paper -“Engineering – The Way Ahead”

Dr. B.S. Nagendra Parashar, Vice Chancellor, Presidency University, Bengaluru,  has published a paper on “Engineering – The Way Ahead” in University News Journal (2017, 55(13), pp 6-9). He also spoke about the same topic on the occasion of Career Utsav 2016 held on 3rd Dec 2016 at Nimhan’s Audiotirium, Bengaluru.
To Read The Paper ClickHere

 

 

Dr. Arabinda Bhandari, Prof. School of Management has published book Strategic Management – A conceptual framework (Mc Graw Hill Education, India )

which is featured in the thesis of Massachusetts Institute of Technology, Cambridge under the supervision of Sloan management review distinguished Prof. of Management Michael . A . Cusumano.

Research topic : How companies can transform from product to platform ecosystem.

 

IN VITRO EVALUATION OF CYTOTOXIC ACTIVITY OF PIPER LONGUM L. ROOT (LONG PEPPER) ON SOME IMPORTANT SPECIES OF BACTERIA

Abstract:

In vitro evaluation of antibacterial activity of aqueous and solvent extract of  Piper longum root was evaluated against five bacterial species viz., Staphylococcus aureus Escherichia coli, Bacillus subtilis, Klebsiella pneumonia  and Pseudomonas  aeruginosa. In aqueous extract tested at 10 to 100% concentration, maximum inhibition was observed in            S. aureus (31.0mm) and B. subtilis (31.0mm) followed by E. coli (30.0mm) and P. aeruginosa (23.0mm). In 10 to 90% concentration, the inhibition percentage was in the range of 5.0 to 29.0 mm respectively. In solvent extract, high percentage of inhibition was observed in petroleum ether extract and recorded a maximum inhibition of 32.0mm and minimum of 27.0mm in all test bacterial species. Petroleum ether extract was followed by methanol, chloroform and ethanol extract. Compared to synthetic antibiotic xanthomycein, chloramphenicol and streptomycein at 25mg concentration, maximum inhibition of  35.0 mm  and minimum of 30.0mm was observed in all the test bacteria. The Minimum Inhibitory Concentration (MIC) was identified for all the test bacterial species.

Key words: Bacteria, Aqueous extract, Solvent extract, MIC, Synthetic antibiotic.

By Dr. Kiran B

Published in : European Journal of Biomedical and Pharmaceutical Sciences

INVESTIGATION OF THE EFFECT OF BIOACTIVE COMPOUND ISOLATED FROM SEEDS OF PSORALEA  CORYLIFOLIA L. ON DNA OF PATHOGENIC BACTERIA

Abstract:

Four species of bacteria viz., Escherichia coli, Staphylococcus aureus,   Bacillus subtilis  and  Xanthomonas sp was treated with 250, 500, 1000 and 1500ppm concentration of the bioactive compound  2H-Furo[2,3-H]-1-benzopyran-2-one isolated from the seeds of Psoralea corylifolia for 24 hours and DNA bands was observed in all the treated bacteria by agarose gel electrophoresis. In control without any treatment of bioactive compound, E. coli, S. aureus,   B. subtilis  and  Xanthomonas sp. recorded 12, 14, 14 and 13 DNA bands respectively. In treated , E. coli,  recorded 14, 15, 16 and 16 at  250, 500, 1000 and 1500ppm concentration,  S. aureus  recorded 14, 15, 16 and 16 , B. subtilis   recorded 15, 16, 17, 17 and Xanthomonas sp. recorded 13, 14, 15 and 16 at 250, 500, 1000 and 1500ppm concentration of the bioactive compound respectively.

Key words: Psoralea corylifolia, bioactive compound, Bacteria, DNA

By Dr. Kiran B

Published in : European Journal of Pharmaceutical and Medical Research

Optical, Dielectric & Ferroelectric Studies on Amino acids Doped TGS Single Crystals.

R. Deepthia and J. Shanthib

  1. Department of Physics, School of Engineering, Presidency University, Bengaluru, Karnataka, India-560 089
  2. Department of Physics, Avinashilingam University for Women, Coimbatore, Tamilnadu, India- 641038.

Abstract:-

Pure TGS and amino acids (L-Arginine, L-Histidine and L-Alanine) doped TGS crystals were grown by slow evaporation solution growth technique at room temperature. The optical transmission window and optical band gap of the crystals were found by UV-vis studies. The cut off wavelength of the grown crystals were observed between 220nm and 290 nm. The dielectric behaviour was investigated at different frequencies and temperatures. AC conductivity was determined. Photoconductivity study reveals that the grown crystals exhibit negative photoconductivity. Ferro electric nature of the crystals was identified by P-E hysteresis loop analysis. Piezoelectric d33 coefficient has been measured for the doped TGS crystals. Two close emission bands in the luminescence spectra in near UV region reveals their application in developing new coherent sources of radiations in this region. . Among the three dopants, L-Arginine doped TGS possesses low dielectric constant and high piezo electric coefficient suggesting that this can be a potential material for infrared detectors.

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Kumar J1,2, Barhydt T1, Awasthi A3, Lithgow GJ1, Killilea DW4, Kapahi P1.

1,2  The Buck Institute for Research on Aging, Novato, California, United States of America.

2DBT-PU-IPLS Programme, Department of Botany/Biotechnology, Patna University, Patna- 800005, Bihar, India.

3Department of Biological Sciences, Birla Institute of Technology and Science, Rajasthan, India.

4Nutrition & Metabolism Center, Children’s Hospital of Oakland Research Institute, Oakland, California, United States of America.

Abstract:

Zinc is an essential trace metal that has integral roles in numerous biological processes, including enzymatic function, protein structure, and cell signaling pathways. Both excess and deficiency of zinc can lead to detrimental effects on development and metabolism, resulting in abnormalities and disease. We altered the zinc balance within Caenorhabditis elegans to examine how changes in zinc burden affect longevity and healthspan in an invertebrate animal model. We found that increasing zinc levels in vivo with excess dietary zinc supplementation decreased the mean and maximum lifespan, whereas reducing zinc levels in vivo with a zinc-selective chelator increased the mean and maximum lifespan in C. elegans. We determined that the lifespan shortening effects of excess zinc required expression of DAF-16, HSF-1 and SKN-1 proteins, whereas the lifespan lengthening effects of the reduced zinc may be partially dependent upon this set of proteins. Furthermore, reducing zinc levels led to greater nuclear localization of DAF-16 and enhanced dauer formation compared to controls, suggesting that the lifespan effects of zinc are mediated in part by the insulin/IGF-1 pathway. Additionally, zinc status correlated with several markers of healthspan in worms, including proteostasis, locomotion and thermotolerance, with reduced zinc levels always associated with improvements in function. Taken together, these data support a role for zinc in regulating both development and lifespan in C. elegans, and that suggest that regulation of zinc homeostasis in the worm may be an example of antagonistic pleiotropy.

Published in: PLoS One. 2016 Apr 14;11(4):e0153513. doi: 10.1371/journal.pone.0153513. eCollection 2016.

Pollution performance of HVAC Insulators: an interpretation using Dimensional Analysis Technique

Abstract: In this research work, the applicability of dimensional analysis has been analysed with respect to the profile dependencies of the porcelain insulator in accordance with its pollution withstand characteristics. Dimensional analysis has been carried out on the influential variables obtained from extensive literature survey. The solution for dimensional equation is obtained by using Buckingham’s pi theorem. The Validity of the arrived equation is checked successfully by fulfilling homogeneity condition. Experimental verification against the arrived dimensional equations are verified with experimental values by carrying out pollution withstand test on various profiles of 400kV porcelain string insulators as per IEC 60507. The profile parameters of the insulator, its influence on pollution withstand characteristic, the co-efficient for corresponding parameters and their validation against experimental investigation are reported and discussed.

Published in:The 19th International Symposium on High Voltage Engineering, Pilsen, Czech Republic, August, 23 – 28, 2015. (available at e-CIGRE library)

Effect of Profiles on Pollution Performance of HVAC Cap& PinPorcelain Insulators

Abstract:From field experience and laboratory study it is clear that the profile of the insulator plays a significant role in the pollution performance of insulators. In this research work, 11 different profiles of cap and pin insulator is analysed for their maximum withstand salinity characteristics for 400 kV system voltage using salt fog testing method. The entire testing procedure and laboratory source characteristic meets the requirement set by IEC 60507. Statistical analysis is carried to find the influence of Unified Specific Creepage Distance (USCD), Diameter, Form Factor, Creepage Factor and Shortest distance between sheds (C). A regression equation is proposed for estimating the maximum withstand salinity of the insulator from its profile parameters. After analysing the co-efficient of determination (R2) and Mean Square Error (MSE), it can be concluded that the calculated results are in good agreement with experimental data. This work can enrich the investigation of insulators parameters and may provide useful reference for performance evaluation and selection of insulators in HV transmission lines.

Presented in: National Conference on Recent Trends in Power Engineering at IIT Madras, December 29-30, 2015

 IN VITRO EVALUTION OF CYTOTOXIC ACTIVITY OF PIPER LONGUM L. ROOT(LONG PEPPER) ON SOME IMPORTANT SPECIES OF  BACTERIA

Abstract:In vitro evaluation of antibacterial activity of aqueous and solvent extract of  Piper longum root was evaluated against five bacterial species viz., Staphylococcus aureus Escherichia coli, Bacillus subtilis, Klebsiella pneumonia  and Pseudomonas  aeruginosa. In aqueous extract tested at 10 to 100% concentration, maximum inhibition was observed in            S. aureus (31.0mm) and B. subtilis (31.0mm) followed by E. coli (30.0mm) and P. aeruginosa (23.0mm). In 10 to 90% concentration, the inhibition percentage was in the range of 5.0 to 29.0 mm respectively. In solvent extract, high percentage of inhibition was observed in petroleum ether extract and recorded a maximum inhibition of 32.0mm and minimum of 27.0mm in all test bacterial species. Petroleum ether extract was followed by methanol, chloroform and ethanol extract. Compared to synthetic antibiotic xanthomycein, chloramphenicol and streptomycein at 25mg concentration, maximum inhibition of  35.0 mm  and minimum of 30.0mm was observed in all the test bacteria. The Minimum Inhibitory Concentration (MIC) was identified for all the test bacterial species.

Key words: Bacteria, Aqueous extract, Solvent extract, MIC, Synthetic antibiotic.

Published in : European Journal of Bio medical and Pharmaceutical Sciences

By Dr. Kiran B

INVESTIGATION OF THE EFFECT OF BIOACTIVE COMPOUND ISOLATED FROM SEEDS OF PSORALEA  CORYLIFOLIA L. ON DNA OF PATHOGENIC BACTERIA

Abstract: Four species of bacteria viz., Escherichia coli, Staphylococcus aureus,   Bacillus subtilis  and  Xanthomonas sp was treated with 250, 500, 1000 and 1500ppm concentration of the bioactive compound  2H-Furo[2,3-H]-1-benzopyran-2-one isolated from the seeds of Psoralea corylifolia for 24 hours and DNA bands was observed in all the treated bacteria by agarose gel electrophoresis. In control without any treatment of bioactive compound, E. coli, S. aureus,   B. subtilis  and  Xanthomonas sp. recorded 12, 14, 14 and 13 DNA bands respectively. In treated , E. coli,  recorded 14, 15, 16 and 16 at  250, 500, 1000 and 1500ppm concentration,  S. aureus  recorded 14, 15, 16 and 16 , B. subtilis   recorded 15, 16, 17, 17 and Xanthomonas sp. recorded 13, 14, 15 and 16 at 250, 500, 1000 and 1500ppm concentration of the bioactive compound respectively.

Key words: Psoralea corylifolia, bioactive compound, Bacteria, DNA

Published in :  European Journal of Pharmaceutical and Medical Research

By Dr. Kiran B

Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Kumar J1,2, Barhydt T1, Awasthi A3, Lithgow GJ1, Killilea DW4, Kapahi P

 1,2  The Buck Institute for Research on Aging, Novato, California, United States of America.

2DBT-PU-IPLS Programme, Department of Botany/Biotechnology, Patna University, Patna- 800005, Bihar, India.

3Department of Biological Sciences, Birla Institute of Technology and Science, Rajasthan, India.

4Nutrition & Metabolism Center, Children’s Hospital of Oakland Research Institute, Oakland, California, United States of America.

Abstract: Zinc is an essential trace metal that has integral roles in numerous biological processes, including enzymatic function, protein structure, and cell signaling pathways. Both excess and deficiency of zinc can lead to detrimental effects on development and metabolism, resulting in abnormalities and disease. We altered the zinc balance within Caenorhabditis elegans to examine how changes in zinc burden affect longevity and healthspan in an invertebrate animal model. We found that increasing zinc levels in vivo with excess dietary zinc supplementation decreased the mean and maximum lifespan, whereas reducing zinc levels in vivo with a zinc-selective chelator increased the mean and maximum lifespan in C. elegans. We determined that the lifespan shortening effects of excess zinc required expression of DAF-16, HSF-1 and SKN-1 proteins, whereas the lifespan lengthening effects of the reduced zinc may be partially dependent upon this set of proteins. Furthermore, reducing zinc levels led to greater nuclear localization of DAF-16 and enhanced dauer formation compared to controls, suggesting that the lifespan effects of zinc are mediated in part by the insulin/IGF-1 pathway. Additionally, zinc status correlated with several markers of healthspan in worms, including proteostasis, locomotion and thermotolerance, with reduced zinc levels always associated with improvements in function. Taken together, these data support a role for zinc in regulating both development and lifespan in C. elegans, and that suggest that regulation of zinc homeostasis in the worm may be an example of antagonistic pleiotropy.

By Dr. Anjali

PLoS One. 2016 Apr 14;11(4):e0153513.

Published in :  doi: 10.1371/journal.pone.0153513. eCollection 2016.

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